Dysoxydensins A–G, Seven New Clerodane Diterpenoids from Dysoxylum densiflorum

Ji Gu; Gui-Guang Cheng; Sheng-Yan Qian; Yan Li; Ya-Ping Liu; Xiao-Dong Luo

doi:10.1055/s-0034-1382903

Planta Medica, Table of Contents

Planta Med 2014; 80(12): 1017-1022
DOI: 10.1055/s-0034-1382903

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Dysoxydensins A–G, Seven New Clerodane Diterpenoids from Dysoxylum densiflorum

Ji Gu^*

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China

²Yuxi China Tobacco Seed Co., Ltd., Yuxi, P. R. China

,

Gui-Guang Cheng^*

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China

,

Sheng-Yan Qian

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China

,

Yan Li

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China

,

Ya-Ping Liu

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China

,

Xiao-Dong Luo

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China

› Author Affiliations

Abstract

Seven new clerodane diterpenoids, dysoxydensins A–G (1–7), together with six known clerodanes, were isolated from Dysoxylum densiflorum. The structures of all the compounds were elucidated by extensive spectroscopic analysis. These compounds were evaluated for their cytotoxic activities against five human cancer cell lines, and compounds 2, 3, and 5 showed moderate cytotoxic activities.

Key words

clerodanes - cytotoxic activities - Dysoxylum densiflorum - Meliaceae

Full Text

References

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